Four physiopathological effects of the venom of Bothrocophias colombianus (Rendahl & Vestergren, 1940) endemic to the colombian Pacific
Toxinological profile of the venom of Bothrocophias colombianus
Abstract
Belonging to the Viperidae family, Crotalinae subfamily, Bothrocophias colombianus, the Colombian toad-headed pitviper or equis colorada, is a species of venomous snake found in the humid rainforests of the Pacific coast of Colombia, where the lack of knowledge of the effects of its venom greatly hinders medical care. Therefore, in an effort to knowledge the effects of the venom B. colombianus venom, gaining an understanding of the local effects by calculating the minimum edematous (MED) and minimum hemorrhagic (MHD) doses, establishing the lethal dose 50 (LD50) in mice of the CFW strain, and examining any systemic effects from a determination of the minimum coagulant dose (MCD) in human blood plasma. The results revealed the LD50 of this venom as 199.5 μg of venom/mouse. There were hemorrhagic (1.06 ± 0.47 μg of ) and edematizing effects (0.45 ± 0.15 μg), in addition to a slight coagulant effect (21.02 ± 0.82 μg). In conclusion, the clinical picture of envenomation caused by this species could be characterized by strong hemorrhagic and edematous alterations and slight impairments in the coagulation cascade.
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